کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5848624 1561699 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of trace element and mineral status and related to levels of amino acid in children with phenylketonuria
ترجمه فارسی عنوان
ارزیابی عناصر کمیاب و مواد معدنی و ارتباط آن با سطوح اسید آمینه در کودکان مبتلا به فنیل کتونوری
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- We evaluate trace elements, amino acids status in children with phenylketonuria.
- We examine whether they were correlated with each other in children with PKU.
- Magnesium might be used as diagnostic index in children with Phenylketonuria.

The aim of the present study was to examine trace elements (Zn, Cu, Mn, Se, Fe, Co, Cr, Ni, Cd, Pb), minerals (Ca, Mg, K), amino acids status in children with phenylketonuria and also whether they were correlated with each other in phenylketonuric patients.It has been found out that the HPA group was significantly lower than the control group with regards to Zn, Se, K, Ca, Mg and Zn/Cr levels (p < 0.001, p < 0.01, p < 0.001, p < 0.01, p < 0.01 and p < 0.001 respectively). In the patients with HPA, significantly strong positive correlations were observed between magnesium and calcium (r = 0.791; p = 0.001), also, indicates negative significant correlation between the concentrations of magnesium and phenylalanine (r = −0.591; p = 0.026).The results of this study showed that, in the HPA group, phenylalanine-Mg relationship found, the presence of disease will in the evaluation of phenylalanine and other amino acids, together with the value of magnesium is required to consider.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 45, July 2016, Pages 302-308
نویسندگان
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