کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849816 | 1561764 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of maternal vitamin B6 deficiency and over-supplementation on DNA damage and oxidative stress in rat dams and their offspring
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
CBSPMPPCEGSHGSSGPLPTBARSPNPmicronucleated polychromatic erythrocyteNCEMicronucleus test - آزمون میکرونوکلئوسnormochromatic erythrocyte - اریتروسیت نورموشروماتیکpolychromatic erythrocyte - اریتروسیت چند رنگیFetal programming - برنامه ریزی جنینیComet assay - روش کامت یا روش سنجش ستاره دنبالهدار thiobarbituric acid reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکMicronucleus - میکروسکوپNutrigenomics - نیتروژنومیکسpyridoxal - پیریدوکسالpyridoxal 5′-phosphate - پیریدوکسال 5'-فسفاتpyridoxamine - پیریدوکسامینpyridoxamine 5′-phosphate - پیریدوکسامین 5'-فسفاتPyridoxine - پیریدوکسینpyridoxine 5′-phosphate - پیریدوکسین 5'-فسفاتreduced glutathione - کاهش گلوتاتیونoxidized glutathione - گلوتاتیون اکسید شده
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Vitamin B6 is a cofactor for more than 140 essential enzymes and plays an important role in maternal health and fetal development. The goal of this study was to investigate the effects of maternal vitamin B6 on DNA damage and oxidative stress status in rat dams and their offspring. Female Wistar rats were randomly assigned to three dietary groups fed a standard diet (control diet), a diet supplemented with 30âmg/kg of vitamin B6, or a deficient diet (0âmg/kg of vitamin B6) for 10 weeks before and during mating, pregnancy and lactation. The dams were euthanized at weaning, and their male pups were euthanized either 10 days or 100 days after birth. We found that maternal vitamin B6 deficiency increased the micronucleus frequency in peripheral blood and bone marrow cells and also increased the concentration of hepatic TBARS (thiobarbituric acid reactive substances) in newborn pups (10 days old). In conclusion, maternal 5- to 6-fold over-supplementation of vitamin B6 had no adverse effects, however its deficiency may induce chromosomal damage and hepatic lipid peroxidation in the offspring.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 80, June 2015, Pages 201-205
Journal: Food and Chemical Toxicology - Volume 80, June 2015, Pages 201-205
نویسندگان
Mara Ribeiro Almeida, VinÃcius Paula Venâncio, Alexandre Ferro Aissa, Joana Darc Castania Darin, Maria Lourdes Pires Bianchi, Lusânia Maria Greggi Antunes,