Keywords: پیریدوکسال 5'-فسفات; One carbon metabolism; Cancer metabolism; Serine hydroxymethyltransferase; Isozymes; Enzyme inhibition; Pyrazolopyran scaffold; Pyridoxal 5â²-phosphate; PLP; serine hydroxymethyltransferase; SHMT; cytosolic SHMT; SHMT1; mitochondrial SHMT; SHMT2; Escheri
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Keywords: پیریدوکسال 5'-فسفات; 5-Aminolevulinate synthase; Pyridoxal phosphate; Heme; Molten globule; Protein unfolding; ALAS; 5-aminolevulinate synthase; mALAS2; murine erythroid-specific 5-aminolevulinate synthase; PLP; pyridoxal 5â²-phosphate; ANS; 8-anilino-1-naphtalenesulfonic ac
Keywords: پیریدوکسال 5'-فسفات; Angiogenesis; Hydrogen sulfide; Molybdenum; Nausea and vomiting of pregnancy; Pyridoxal 5â²-phosphate; Sulfite oxidase;
Keywords: پیریدوکسال 5'-فسفات; Folate; Homocysteine; Pyridoxal 5â²-phosphate; Methylenetetrahydrofolate reductase; Colorectal cancer;
Keywords: پیریدوکسال 5'-فسفات; GAD; Glutamate decarboxylase; CaM1; calmodulin isoform 1 from Arabidopsis thaliana; GABA; γ-aminobutyric acid; PLP; pyridoxal 5â²-phosphate; PDB; Protein Data Bank; Kd; dissociation constant; SEC; size exclusion chromatography; FPLC; fast protein liquid
Keywords: پیریدوکسال 5'-فسفات; AECK; aminoethylcysteine ketimine; AECK-DD; aminoethylcysteine ketimine decarboxylated dimer; CβS; cystathionine-β-synthase, L-serine hydro-lyase; CγL; cystathionine-γ-lyase, L-cystathionine cysteine-lyase, CSE; CRMP2; collapsin response mediator prot
Keywords: پیریدوکسال 5'-فسفات; Homocysteine; Cysteine; Pyridoxal 5â²-phosphate; Oxidative stress; Antioxidant capacities; Colorectal cancer;
Keywords: پیریدوکسال 5'-فسفات; AC; adenylate cyclase; AD; Alzheimer's disease; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; AOAA; aminooxyacetate; cAMP; cyclic adenosine monophosphate; CBS; cystathionine β-synthase; CNS; central nervous system; CSE; cystathionine
Keywords: پیریدوکسال 5'-فسفات; DHPE; 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine; DHPS; 1,2-dihexanoyl-sn-glycero-3-phospho-l-serine; PE; phosphatidylethanolamine; PEA; O-phosphorylethanolamine; PS; phosphatidylserine; PSer; O-phospho-dl-serine; PLP; pyridoxal 5â²-phosphate; PM; p
Comment on the frequently used method of the metal complex-DNA binding constant determination from UV-Vis data
Keywords: پیریدوکسال 5'-فسفات; Pyridoxal 5â²-phosphate; Hydrazone; DNA; Binding constant; UV-Vis spectroscopy;
Structural and enzymatic properties of mammalian d-glutamate cyclase
Keywords: پیریدوکسال 5'-فسفات; d-Glutamate cyclase; Metalloenzyme; d-Glutamate; d-Amino acid; Mitochondria; Heart failure; DAO; d-amino acid oxidase; DGLUCY; d-glutamate cyclase; DDO; d-aspartate oxidase; EC50; 50% effective concentration; EDC; 1-(3-dimethylaminopropyl)-3-ethylcarbodii
Molecular and cellular basis of ornithine δ-aminotransferase deficiency caused by the V332M mutation associated with gyrate atrophy of the choroid and retina
Keywords: پیریدوکسال 5'-فسفات; OAT; ornithine δ-aminotransferase; PLP; pyridoxal 5â²-phosphate; GA; gyrate atrophy; L-Orn; L-ornithine; GSA; glutamic-γ-semialdehyde; α-KG; α-ketoglutarate; P5C; pirroline-5-carboxylate; OATwt; OAT wild-type; OATV332M; OAT bearing the V332M mutation
The dichotomous role of H2S in cancer cell biology? Déjà vu all over again
Keywords: پیریدوکسال 5'-فسفات; 1400 W; N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide; 3-MP; 3-Mercaptopyruvate; 3-MST; 3-Mercaptopyruvate sulfurtransferase; ADT-OH; 5-(4-hydroxyphenyl)-3H-1, 2-dithiole-3-thione; AG; Aminoguanidine; AOAA; Aminooxyacetic acid; CAT; Cysteine aminotra
Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity
Keywords: پیریدوکسال 5'-فسفات; Cysteine desulfurase; Friedreich's ataxia; Iron-sulfur cluster; ISCU; Zinc; ACP; acyl carrier transfer protein; BLI; BioLayer interferometry; BSA; bovine serum albumin; CD; circular dichroism; DMPD; N,N-dimethyl-p-phenylenediamine; DSF; differential scann
Serine 51 residue of Citrobacter freundii tyrosine phenol-lyase assists in C-α-proton abstraction and transfer in the reaction with substrate
Keywords: پیریدوکسال 5'-فسفات; Tyrosine phenol-lyase; Pyridoxal 5â²-phosphate; Mutant form Ser51Ala; C-α-proton abstraction; Guiding role of serine-51; TPL; tyrosine phenol-lyase; PLP; pyridoxal 5â²-Ñhosphate; WT; wild type; Ser51Ala; mutant enzyme with Ser51 replaced by Ala; SOPC;
Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro
Keywords: پیریدوکسال 5'-فسفات; âÏm; mitochondrial membrane potential; CHOP; C/EBP homologous protein; CsA; cyclosporine A; DMSp; deoxymethylsphinganine; DRG; dorsal root ganglia; DSp; deoxysphinganine; ER; endoplasmic reticulum; FCCP; carbonyl cyanide-p-trifluoromethoxyphenylhydrazo
Measurement of pyridoxal 5â²-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children
Keywords: پیریدوکسال 5'-فسفات; AED; anti-epileptic drugs; PA; 4-pyridoxic acid; PDXK; pyridoxal kinase; PL; pyridoxal; PLP; pyridoxal 5â²-phosphate; PNPO; pyridox[am]ine-phosphate oxidase; Pyridoxal phosphate; 4-pyridoxic acid; Vitamin B6; Liquid chromatography; Fluorescence detection
Crystal structure of mutant form Cys115His of Citrobacter freundii methionine γ-lyase complexed with l-norleucine
Keywords: پیریدوکسال 5'-فسفات; MGL; methionine γ-lyase; PEG MME; polyethylene glycol monomethyl ether; PLP; pyridoxal 5â²-phosphate; Pyridoxal 5â²-phosphate-dependent methionine γ-lyase; C115H mutant form; Three-dimensional structure;
Pyridoxal 5â²-phosphate mediated preparation of immobilized metal affinity material for highly selective and sensitive enrichment of phosphopeptides
Keywords: پیریدوکسال 5'-فسفات; Phosphopeptide enrichment; Rat brain; Pyridoxal 5â²-phosphate; Immobilized metal affinity chromatography;
Optimal electrostatic interactions between substrate and protein are essential for radical chemistry in ornithine 4,5-aminomutase
Keywords: پیریدوکسال 5'-فسفات; AdoCbl; adenosylcobalamin; Ado; 5â²-deoxyadenosyl radical; AdoH; 5â²-deoxyadenosine; OAM; ornithine 4,5-aminomutase; 5,6-LAM; lysine 5,6-aminomutase; PLP; pyridoxal 5â²-phosphate; DAPDH; 2,4-diaminopentanoic acid dehydrogenase; NAD+;  β-nicotinamide
Use of polymer conjugates for the intraperoxisomal delivery of engineered human alanine:glyoxylate aminotransferase as a protein therapy for primary hyperoxaluria type I
Keywords: پیریدوکسال 5'-فسفات; Protein therapeutics; Polymer conjugates; Primary hyperoxaluria; Rare disease; Peroxisomal targeting; Enzyme administration; PH1; primary hyperoxaluria type I; AGT; alanine:glyoxylate aminotransferase; PLP; pyridoxal 5â²-phosphate; PTS; peroxisomal targe
Isoniazid inhibits human erythroid 5-aminolevulinate synthase: Molecular mechanism and tolerance study with four X-linked protoporphyria patients
Keywords: پیریدوکسال 5'-فسفات; ALA; 5-aminolevulinic acid; ALAS1; non-specific isoform of 5-aminolevulinate synthase; ALAS2; erythroid-specific isoform of 5-aminolevulinate synthase; mALAS2; erythroid-specific isoform of murine 5-aminolevulinate synthase; ÎmALAS2; erythroid-specific i
Pyridoxal 5â²-phosphate, pyridoxal, and 4-pyridoxic acid in the paired serum and cerebrospinal fluid of children
Keywords: پیریدوکسال 5'-فسفات; TNSALP; tissue non-specific alkaline phosphatase; PA; 4-pyridoxic acid; PL; pyridoxal; PLP; pyridoxal 5â²-phosphate; Vitamin B6; Phosphorylation; Dephosphorylation; Transport; Blood-CSF barrier; Liquid chromatography; Fluorescence detection;
Crystal structure of a photolysis product of vitamin B6: A pyridodihydrofuran-condensed skeleton compound of pyridoxal 5â²-phosphate
Keywords: پیریدوکسال 5'-فسفات; Crystal structure; Photolysis product; Vitamin B6; Pyridoxal 5â²-phosphate; Pyridodihydrofuran; Graph set analysis of hydrogen bonding patterns;
Applications of vitamin B6 cofactor pyridoxal 5â²-phosphate and pyridoxal 5â²-phosphate crowned gold nanoparticles for optical sensing of metal ions
Keywords: پیریدوکسال 5'-فسفات; Optical sensing; Vitamin B6 cofactor; Pyridoxal 5â²-phosphate; Functionalized gold nanoparticles; Multiple-metal ions;
Isolation and characterization of the 5â²-flanking region of the human PDXK gene
Keywords: پیریدوکسال 5'-فسفات; PN; pyridoxine; PM; pyridoxamine; PL; pyridoxal; PNP; pyridoxine 5â²-phosphate; PMP; pyridoxamine 5â²-phosphate; PLP; pyridoxal 5â²-phosphate; Pyridoxal kinase; Promoter; Regulatory region; Sp1 binding site;
A Novel highly thermostable branched-chain amino acid aminotransferase from the crenarchaeon Vulcanisaeta moutnovskia
Keywords: پیریدوکسال 5'-فسفات; BCAA; branched-chain amino acid; BCAT; branched-chain amino acid aminotransferase; PLP; pyridoxal 5â²-phosphate; PMP; pyridoxamine 5â²-phosphate; (R)-MBA; (R)-α-methylbenzylamine; AlaDH; alanine dehydrogenase; LDH; lactate dehydrogenase; Branched-chain
Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior
Keywords: پیریدوکسال 5'-فسفات; Serine hydroxymethyltransferase; Pyridoxal 5â²-phosphate; Tetrahydrofolate; Ligand binding; Rapid-quench flow; Substrate inhibition; Rate determining step;
Research paperDirect and indirect effects of RNA interference against pyridoxal kinase and pyridoxine 5â²-phosphate oxidase genes in Bombyx mori
Keywords: پیریدوکسال 5'-فسفات; PN; pyridoxine; PM; pyridoxamine; PL; pyridoxal; PNP; pyridoxine 5â²-phosphate; PMP; pyridoxamine 5â²-phosphate; PLP; pyridoxal 5â²-phosphate; Bombyx mori; RNA interference; Pyridoxal kinase; Pyridoxine 5â²-phosphate oxidase; Phosphoserine aminotransf
Ophthalmic acid accumulation in an Escherichia coli mutant lacking the conserved pyridoxal 5â²-phosphate-binding protein YggS
Keywords: پیریدوکسال 5'-فسفات; Pyridoxal 5â²-phosphate; Ophthalmic acid; YggS; Escherichia coli; Glutathione; Amino acid;
Crystal structure and catalytic mechanism of pyridoxal kinase from Pseudomonas aeruginosa
Keywords: پیریدوکسال 5'-فسفات; Pseudomonas aeruginosa; Pyridoxal kinase; Pyridoxal 5â²-phosphate; Crystal structure;
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming
Keywords: پیریدوکسال 5'-فسفات; SHMT; serine hydroxymethyltransferase; SHMT1; cytosolic SHMT; SHMT2; mitochondrial SHMT; 3BP; 3-bromopyruvate; PLP; pyridoxal 5â²-phosphate; H4PteGlu; tetrahydropteroylglutamate; Cancer metabolic reprogramming; Serine hydroxymethyltransferase; Isozymes;
Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine β-synthase
Keywords: پیریدوکسال 5'-فسفات; H2S; hydrogen sulfide; NO; nitric oxide; CO; carbon monoxide; CcOX; cytochrome c oxidase; CBS; cystathionine β-synthase; AdoMet; S-adenosyl-l-methionine; CGL; cystathionine γ-lyase; PLP; pyridoxal 5â²-phosphate; MST; 3-mercaptopyruvate sulfurtransferas
Fluorination at the 4 position alters the substrate behavior of l-glutamine and l-glutamate: Implications for positron emission tomography of neoplasias
Keywords: پیریدوکسال 5'-فسفات; AAT; l-α-aminoadipate aminotransferase; AlaAT; alanine aminotransferase; AOAA; aminooxyacetate; AspAT; aspartate aminotransferase; FP-Gln; (2S,4S)-4-(3-fluoropropyl)-l-glutamine; 4-FGln; l-4-fluoroglutamine (chirality at the 4 position not specified); (2
Interaction between cysteine synthase and serine O-acetyltransferase proteins and their stage specific expression in Leishmania donovani
Keywords: پیریدوکسال 5'-فسفات; Cysteine synthase; Serine O-acetyltransferase; Leishmania; Enzyme kinetics; Trypanothione; Thiol metabolism; Amp B; amphotericin B; CS; cysteine synthase; CBS; cystathionine β-synthase; CGS; cystathionine γ-lyase; DTNB; 5,5â²-dithiobis-(2-nitrobenzoic
Enzymatic diagnosis of homocystinuria by determination of cystathionine-Ã-synthase activity in plasma using LC-MS/MS
Keywords: پیریدوکسال 5'-فسفات; CBS; Cystathionine Ã-synthase; EDTA; Ethylenediaminetetracetic acid; DTT; Dithiothreitol; IEM; Inborn errors of metabolism; IS; Internal standard; LC-MS/MS; Liquid chromatography-tandem spectrometry; MoM; Multiples of median; PLP; Pyridoxal 5â²-phosphat
Effects of maternal vitamin B6 deficiency and over-supplementation on DNA damage and oxidative stress in rat dams and their offspring
Keywords: پیریدوکسال 5'-فسفات; Pyridoxine; Comet assay; Micronucleus test; Fetal programming; Nutrigenomics; CBS; cystathionine synthase; GSH; reduced glutathione; GSSG; oxidized glutathione; MN; micronucleus; MN PCE; micronucleated polychromatic erythrocyte; PCE; polychromatic erythro
Molecular basis of E. colil-threonine aldolase catalytic inactivation at low pH
Keywords: پیریدوکسال 5'-فسفات; Pyridoxal 5â²-phosphate; Threonine aldolase; Internal aldimine; Transaldimination; PLP-dependent enzymes; Protein crystallography;
IscS from Archaeoglobus fulgidus has no desulfurase activity but may provide a cysteine ligand for [Fe2S2] cluster assembly
Keywords: پیریدوکسال 5'-فسفات; l-cysteine desulfurase; Pyridoxal 5â²-phosphate; 5â²-pyridoxamine; Schiff base; IscS; Archaeoglobus fulgidus;
On the mechanism of Escherichia coli pyridoxal kinase inhibition by pyridoxal and pyridoxal 5â²-phosphate
Keywords: پیریدوکسال 5'-فسفات; PLP; pyridoxal 5â²-phosphate; PNP; pyridoxine 5â²-phosphate; PN; pyridoxine; PL; pyridoxal; ePLK1; E. coli pyridoxal kinase encoded by pdxK gene; ePLK2; E. coli pyridoxal kinase encoded by pdxY gene; saPLK; Staphylococcus aureus pyridoxal kinase; Pyrido
Murine erythroid 5-aminolevulinate synthase: Adenosyl-binding site Lys221 modulates substrate binding and catalysis
Keywords: پیریدوکسال 5'-فسفات; ALA; 5-aminolevulinic acid; ALAS2; erythroid specific isoform of 5-aminolevulinate synthase; mALAS2; erythroid specific isoform of murine 5-aminolevulinate synthase; PLP; pyridoxal 5â²-phosphate; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel elec
Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy
Keywords: پیریدوکسال 5'-فسفات; Vitamin B deficiency; Type 2 diabetes; Microalbuminuria; Pyridoxal 5â²-phosphate;
The role of active site tyrosine 58 in Citrobacter freundii methionine γ-lyase
Keywords: پیریدوکسال 5'-فسفات; MGL; methionine γ-lyase; PLP; pyridoxal 5â²-phosphate; Tyr58Phe; mutant enzyme with Tyr58 replaced by Phe; LDH; lactate dehydrogenase; HOHxoDH; d-2-hydroxyisocaproate dehydrogenase; Methionine γ-lyase; Pyridoxal 5â²-phosphate; Mutant form; Cofactor-bi
Oral exposure to the anti-pyridoxine compound 1-amino d-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B6 deficient rats
Keywords: پیریدوکسال 5'-فسفات; 1ADP; 1-amino d-proline; 4-PA; 4-pyridoxic acid; CBS; cystathionine β-synthase; CGL; cystathionine γ-lyase; CTH; cystathionine; Cys; cysteine; Hcy; homocysteine; PL; pyridoxal; PLP; pyridoxal 5â²-phosphate; PN·HCl; pyridoxine·hydrochloride; 1-Amino d
Misfolding caused by the pathogenic mutation G47R on the minor allele of alanine:glyoxylate aminotransferase and chaperoning activity of pyridoxine
Keywords: پیریدوکسال 5'-فسفات; PH1; Primary Hyperoxaluria Type I; AGT; alanine:glyoxylate aminotransferase; PLP; pyridoxal 5â²-phosphate; MTS; mitochondrial targeting sequence; CHO; Chinese hamster ovary; GO; glycolate oxidase; PBS; phosphate buffered saline; KD(PLP); PLP equilibrium
Structure and function of Mycobacterium smegmatis 7-keto-8-aminopelargonic acid (KAPA) synthase
Keywords: پیریدوکسال 5'-فسفات; KAPA; 7-keto-8-aminopelargonic acid; PLP; pyridoxal 5â²-phosphate; ADS; albumin-dextrose-saline; TEV; tobacco etch virus; KAM; N-(7-keto-8-aminopelargonic acid)-(3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane); PDB; Protein Data Bank; Mycob
A subfamily of PLP-dependent enzymes specialized in handling terminal amines
Keywords: پیریدوکسال 5'-فسفات; PLP; pyridoxal 5â²-phosphate; PMP; pyridoxamine 5â²-phosphate; α-KG; α-ketoglutarate; GABA; γ-aminobutyrate; AT; aminotransferase; AT-I; subgroup-I aminotransferases; AT-II; subgroup-II aminotransferases (also denominated class-III aminotransferases,
A method for determining δ-aminolevulinic acid synthase activity in homogenized cells and tissues
Keywords: پیریدوکسال 5'-فسفات; ALA; δ-aminolevulinic acid; ALAS; δ-aminolevulinic acid synthase; PLP; pyridoxal 5â²-phosphate; UPLC; ultra performance liquid chromatography; MEL; mouse erythroleukemia cells; DMSO; dimethylsulfoxide; PDA; photodiode array detector; UV; ultraviolet; s
Facile “stop codon” method reveals elevated neuronal toxicity by discrete S87p-α-synuclein oligomers
Keywords: پیریدوکسال 5'-فسفات; Stop codon; Phosphorylation; Oligomerization; Pyridoxal 5â²-phosphate; Copper; Dopamine;
Crystal structure of the external aldimine of Citrobacter freundii methionine γ-lyase with glycine provides insight in mechanisms of two stages of physiological reaction and isotope exchange of α- and β-protons of competitive inhibitors
Keywords: پیریدوکسال 5'-فسفات; Pyridoxal 5â²-phosphate dependent enzyme; Methionine γ-lyase; Isotopic exchange of protons; Concerted mechanism; Stereoselectivity; MGL; methionine γ-lyase; PLP; pyridoxal 5â²-phosphate;