کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5850031 1561770 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro evaluation of inorganic mercury and methylmercury effects on the intestinal epithelium permeability
ترجمه فارسی عنوان
بررسی در معرض اثرات جیوه معدنی و متیل کربن بر نفوذ پذیری اپیتلیوم روده
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی
The experiments made show the mercurial forms generate reactive oxygen and/or nitrogen species and a significant decrease in glutathione contents. This redox imbalance could be the cause of the lipid peroxidation observed after short exposure times. Such conditions of stress lead to a modulation of stress proteins, intercellular junction proteins and tumor necrosis factor-alpha expression and to a redistribution of F-actin and ZO1 protein in the intestinal monolayer. The abovementioned effects may be the cause of the increase in permeability in the differentiated cells observed at concentrations similar to those found in food products (0.5-1 mg/L). The increase in permeability could produce an impairment of the barrier function of the intestinal epithelium.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 74, December 2014, Pages 349-359
نویسندگان
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