کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5851105 1561785 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular mechanisms involved in the protective effect of selenocystine against methylmercury-induced cell death in human HepG2 cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Molecular mechanisms involved in the protective effect of selenocystine against methylmercury-induced cell death in human HepG2 cells
چکیده انگلیسی
Combined treatment of SeCys and MeHg protected HepG2 cells against MeHg-induced cell damage, showing this selenocompound a more relevant effect than those of selenium methylselenocysteine and selenium methionine. Co-treatment with SeCys exerted a protective effect against MeHg by restraining ROS generation and glutathione decrease, and through the modulation of antioxidant enzymes activities. In addition, SeCys delayed MeHg-induced apoptosis and prevented extracellular regulated kinases (ERKs) deactivation, as well as p38 and c-Jun N-terminal kinase (JNK) stimulations in comparison to MeHg-treated cells. ERK, JNK and p38 involvement on the protective effect of SeCys against MeHg-induced cell damage was confirmed by using selective inhibitors. All these results indicate that SeCys protects against MeHg-induced cell damage by modulating the redox status and key proteins related to cell stress and survival/proliferation pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 59, September 2013, Pages 554-563
نویسندگان
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