Lack of cytotoxic and genotoxic effects of Minthostachys verticillata essential oil: Studies in vitro and in vivo

► Toxicity and chemical composition of Minthostachys verticillata essential oil were studied. ► The main compounds were pulegone, menthone and limonene. ► The essential oil not induced cytotoxic effect both on Vero cell and human PBMCs. ► The oil not induced apoptosis on human PBMCs nor genotoxicity on erythrocytes of mice. ► The results suggest this species appears to be a safe therapeutic agent.