کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5852697 1130852 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DNA damage in organs of mice treated acutely with patulin, a known mycotoxin
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
DNA damage in organs of mice treated acutely with patulin, a known mycotoxin
چکیده انگلیسی
► Genotoxic effect of patulin after systemic administration was evaluated in mice. ► Dose-dependent increase in DNA strand breaks (brain, liver, kidneys) was detected. ► Decreased level of GSH and increased lipid peroxidation were also observed. ► Pre-treatment with N-acetyl-cysteine restored GSH levels and reduced DNA damage. ► Our results showed correlation between pro-oxidant and genotoxic effects of patulin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 50, Issue 10, October 2012, Pages 3548-3555
نویسندگان
, , , , , , , ,