DNA damage in organs of mice treated acutely with patulin, a known mycotoxin

► Genotoxic effect of patulin after systemic administration was evaluated in mice. ► Dose-dependent increase in DNA strand breaks (brain, liver, kidneys) was detected. ► Decreased level of GSH and increased lipid peroxidation were also observed. ► Pre-treatment with N-acetyl-cysteine restored GSH levels and reduced DNA damage. ► Our results showed correlation between pro-oxidant and genotoxic effects of patulin.