کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5853826 | 1130867 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selenium reverses Pteridium aquilinum-induced immunotoxic effects
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کلمات کلیدی
TLCPerCP-Cy5.5CFSERBCWBCDCMFITCFBSnatural killer - (سلول های) کشنده طبیعیDMSO - DMSOMTT - MTTUltraviolet - اشعه فرابنفشstandard deviation - انحراف معیارBrdU - بروموداکسی اوریدینbromodeoxyuridine - برومودسوویریدینThiazolyl blue tetrazolium bromide - تترازولیم برومید تیزولیل آبیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceDichloromethane - دیکلورمتانDimethyl sulfoxide - دیمتیل سولفواکسیدfetal bovine serum - سرم جنین گاوSelenium - سلنیومNatural killer cell - سلول قاتل طبیعیImmunotoxicity - سمیت ایمنیCytotoxicity - سمیت سلولیphycoerythrin - فایکوئیریدینfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتPtaquiloside - پتاویولوزیدPropidium iodide - پروتئین یدیدthin layer chromatography - کروماتوگرافی لایه نازکwhite blood cell - گلبول سفید خونred blood cell - گلبول قرمز، اریتروسیت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
We have previously shown that bracken fern (Pteridium aquilinum) has immunomodulatory effects on mouse natural killer (NK) cells by reducing cytotoxicity. Alternatively, it has been demonstrated that selenium can enhance NK cell activity. Therefore, the aims of the present study were to evaluate if ptaquiloside, the main toxic component found in P. aquilinum, is responsible for the immunotoxic effects observed in mice, and if selenium supplementation could prevent or even reverse these effects. Male C57BL/6 mice were administered the P. aquilinum extract by daily gavage for 30Â days, and histological analyses revealed a significant reduction in splenic white pulp area that was fully reversed by selenium treatment. In addition, mice administered ptaquiloside by daily gavage for 14Â days demonstrated the same reduction of NK cell activity as the P. aquilinum extract, and this reduction was prevented by selenium co-administration. Lastly, non-adherent splenic cells treated in vitro with an RPMI extract of P. aquilinum also showed diminished NK cell activity that was not only prevented by selenium co-treatment but also fully reversed by selenium post-treatment. The results of this study clearly show that the immunosuppressive effects of P. aquilinum are induced by ptaquiloside and that selenium supplementation can prevent as well as reverse these effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 49, Issue 2, February 2011, Pages 464-470
Journal: Food and Chemical Toxicology - Volume 49, Issue 2, February 2011, Pages 464-470
نویسندگان
A.O. Latorre, B.D. Caniceiro, H.L. Jr., M. Haraguchi, D.R. Gardner, S.L. Górniak,