کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5854171 | 1130885 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart
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کلمات کلیدی
left ventricular peak systolic pressureMDALangendorffLVSPLVEDPGSHLVDPLVPTTCEDPROS - ROSAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPischemia/reperfusion - ایسکمی / رپرفیوژنLeft ventricular developed pressure - بطن چپ توسعه یافته فشارanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceOxidative stress - تنش اکسیداتیوPanax ginseng - جینسنگ PanaxHeart rate - ضربان قلبCardiac function - عملکرد قلبیleft ventricular pressure - فشار بطن چپend-diastolic pressure - فشار دیستال پایینleft ventricular end-diastolic pressure - فشار پای دیاستولیک بطن چپlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH malondialdehyde - مالون دی آلدهیدreduced glutathione - کاهش گلوتاتیونCreatine kinase - کراتین کینازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart](/preview/png/5854171.png)
چکیده انگلیسی
The aim of the present study was to evaluate the protective effect of ginseng total saponin, panaxadiol and panaxatriol, which are the major components of Panax ginseng, against myocardial ischemia/reperfusion (I/R) injury in isolated rat hearts. Rats were orally administered once a day with total saponin (20Â mg/kg), panaxadiol (5Â mg/kg) and panaxatriol (5Â mg/kg) for consecutive 7Â days. On day 8, the hearts were isolated and perfused with Krebs-Henseleit bicarbonate buffer solution using Langendorff apparatus. After 30Â min of global ischemia, hearts were reperfused for 30Â min. Myocardial function, coronary flow and biochemical parameters, such as lactate dehydrogenase (LDH), creatine kinase (CK), adenosine triphosphate (ATP), malondialdehyde (MDA) and reduced glutathione (GSH) were measured. Total saponin and panaxatriol significantly improved I/R-induced myocardial dysfunction by increasing left ventricular development pressure, (âdP/dt)/(+dP/dt) and time to contracture. Moreover, the increases in the levels of LDH, CK and MDA and the decrease in the levels of GSH were attenuated by total saponin and panaxatriol. However, the ATP levels did not affected by total saponin, panaxadiol and panaxatriol pretreatment. Our findings suggest that pretreatment with ginseng total saponin, especially panaxatriol, ameliorates I/R-induced myocardial damage and this protection is caused by reducing oxidative stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 48, Issue 6, June 2010, Pages 1516-1520
Journal: Food and Chemical Toxicology - Volume 48, Issue 6, June 2010, Pages 1516-1520
نویسندگان
Tae-Hoon Kim, Sun-Mee Lee,