Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus

► Fe3O4-NPs deposit in striatum and hippocampus related PD and AD. ► Fe3O4-NPs decrease neurons viability, trigger oxidative stress in vitro. ► JNK/P53 signalling pathway is activated by Fe3O4-NPs at 100 μg/ml.