کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5855722 | 1562122 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A subchronic toxicity study of Radix Dipsaci water extract by oral administration in F344 rats
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کلمات کلیدی
EBMCREALUCALTAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییtriglyceride - تریگلیسریدBUN - خوبTraditional medicines - داروهای سنتیWorld Health Organization - سازمان بهداشت جهانیlarge unstained cells - سلول های بی نظیر بزرگSubchronic toxicity - سمیت زیر سونوگرافیPhospholipid - فسفولیپیدblood urea nitrogen - نیتروژن اوره خونbody weight - وزن بدنEvidence based medicine - پزشکی مبتنی بر شواهدcreatinine - کراتینینtotal cholesterol - کلسترول تامWHO - کهGlu - گلوGlucose - گلوکز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A subchronic toxicity study of Radix Dipsaci water extract by oral administration in F344 rats A subchronic toxicity study of Radix Dipsaci water extract by oral administration in F344 rats](/preview/png/5855722.png)
چکیده انگلیسی
Radix Dipsaci, the dried root of Dipsacus asperoides C.Y. Cheng & T.M.Ai, has therapeutic effects on various disorders, and in particular, bone and joint disease. Despite such ethnomedicinal benefits, there is very little information regarding its in vivo toxicity or adverse effects. This study was conducted to evaluate the potential toxicity of the Radix Dipsaci water Extract (RD-wE) by using F344 rats. The RD-wE was administered orally to rats at doses of 0, 125, 250, 500, 1000, and 2000 mg/kg body weight (bw)/day for 13 weeks. During the treatment period there were no mortalities attributed to RD-wE. Moreover, no toxic effects were observed with regard to body weight, clinical pathology (hematology, clinical biochemistry, and urinalysis), and anatomic pathology (gross findings, organ weight, and microscopic examination). The changes related to the treatment were excessive salivation at the mouth and soft feces, observed in male and female rats at 1000 or 2000 mg/kg bw/day, but these were not accompanied by any microscopic correlate or other pathophysiological changes. Based on these results, the oral no-observed-adverse-effect level of the RD-wE was considered to be 2000 mg/kg bw/day in both genders, although the target organs were not determined under the current experimental conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 81, November 2016, Pages 136-145
Journal: Regulatory Toxicology and Pharmacology - Volume 81, November 2016, Pages 136-145
نویسندگان
Ji-Seok Han, Byoung-Seok Lee, So-Ri Han, Hyoung-Yun Han, Moon-Koo Chung, Byung-Sun Min, Ji Hyeon Seok, Yong-Bum Kim,