کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5855883 1562123 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of muffle furnace preparation on the results of crystalline silica analysis
ترجمه فارسی عنوان
تاثیر آماده سازی کوره های صدا خفه کننده بر نتایج تجزیه و تحلیل سیلیس بلوری
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Shipping cassettes loaded with crystalline silica did not appear to significantly affect the results.
- Muffle furnace sample preparation had lower recoveries than plasma ashing sample preparation.
- The recoveries from muffle furnace ashing are affected by the level of effort expended in scraping the crucibles.
- The data are suggestive of areas of the analytical process that OSHA should further investigate for improvement.

A prior report demonstrated an unacceptably low level of accuracy in silica analytical testing, with a general negative bias (i.e., underreporting) although other inaccuracies included false-positive results when analyzing blank filters. The possible bias may have been due to the loss of sample during shipping and or sample preparation. We report on a follow-up study that was designed to mimic the original study, but in which sources of variability were evaluated. We found no effect on silica recoveries due to shipping and confirmed the prior study results that the muffle furnace ashing process led to low overall recoveries (49-104%), depending on the adherence to the recommended preparation method. Plasma ashing recoveries ranged from 89 to 108%. Our results suggest that muffle-furnace ashing using a crucible should be restricted. More broadly, however, muffle-furnace ashing is only one source of analytical error that contributes to the relatively poor overall performance revealed by Cox et al. Whatever the case, OSHA should ensure that its proposed requirements to improve laboratory performance will actually lead to the discovery and correction of all major sources of error by participating laboratories. This is particularly important in light of OSHA's proposed reduction in the PEL and action level proposed by OSHA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 80, October 2016, Pages 164-172
نویسندگان
, , , , ,