کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5856345 | 1131973 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Children's liver chemistries vary with age and gender and require customized pediatric reference ranges
ترجمه فارسی عنوان
شیمیدان های کبدی کودکان با سن و جنس متفاوت است و نیازمند محدوده مرجع کودکانه سفارشی است
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کلمات کلیدی
NAFLDALTNHANESTBILULNPediatric clinical trials - آزمایشات بالینی کودکانAspartate aminotransaminase - آسپارتات آمینوترانسامینازAST - آسپارتات ترانس آمینازAlanine aminotransferase - آلانین آمینوترانسفرازALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییNational Health and Nutrition Examination Survey - بررسی بهداشت و تغذیه ملیNonalcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیUpper limit of normal - حد بالای طبیعیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیtotal bilirubin - کل بیلی روبین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Used to detect liver disease and injury, baseline liver chemistry distributions were evaluated by age and gender in children without known liver disease. Baseline liver chemistries [alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TBIL)] were analyzed from 24 randomized controlled pediatric clinical trials. Using quantile regression, liver chemistry distributions were examined by age and gender; upper limit normal (ULN) ranges were compared to the 97.5th percentiles of the distributions for the specified ages and genders. 5410 subjects without known liver disease (0-18 years; 60% male) were studied. The median ALT varied little with age. In males age 5-18, the ALT 97.5th percentile increased from 34 to 63Â IU/L. In both genders, the median and 97.5th percentile AST decreased with age. After age 9, ALP decreased. TBIL increased with age. Despite most liver chemistry 97.5th percentiles changing substantively with age and gender, the reference lab ULN generally changed minimally and did not correlate with the 97.5th percentile. Gender and age specific 97.5th percentile data should therefore be considered for the reference laboratory ULN in children to more accurately detect liver injury and disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 73, Issue 1, October 2015, Pages 349-355
Journal: Regulatory Toxicology and Pharmacology - Volume 73, Issue 1, October 2015, Pages 349-355
نویسندگان
Heide A. Stirnadel-Farrant, Nicholas Galwey, Chanchal Bains, Caroline Yancey, Christine M. Hunt,