کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5856396 | 1562127 | 2016 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carcinogenicity and chronic toxicity of hydrazine monohydrate in rats and mice by two-year drinking water treatment
ترجمه فارسی عنوان
سرطان زایی و سمیت مزمن هیدرازین مونوهیدرات در موش و موش ها با دو سال درمان آب آشامیدنی
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کلمات کلیدی
هیدرازین مونوهیدرات، سمیت مزمن، سرطان زایی موش موش، کبد،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
The carcinogenicity and chronic toxicity of hydrazine monohydrate was examined by administrating hydrazine monohydrate in drinking water to groups of 50 F344/DuCrj rats and 50 Crj:BDF1 mice of both sexes for two years. The drinking water concentration of hydrazine monohydrate was 0, 20, 40 or 80Â ppm (wt/wt) for male and female rats and male mice; and 0, 40, 80 or 160Â ppm for female mice. Survival rates of each group of males and females rats and mice were similar to the respective controls, except female rats administered 80Â ppm. Two-year administration of hydrazine monohydrate produced an increase in the incidences of hepatocellular adenomas and carcinomas in rats of both sexes along with hepatic foci. In mice, the incidences of hepatocellular adenomas and carcinomas were increased in females, and significantly increased incidences of hepatocellular adenomas in females administered 160Â ppm were observed. Thus, hydrazine monohydrate is carcinogenic in two species, rats and mice. Additionally, non-neoplastic renal lesions in rats and mice and non-neoplastic nasal lesions in mice were observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 76, April 2016, Pages 63-73
Journal: Regulatory Toxicology and Pharmacology - Volume 76, April 2016, Pages 63-73
نویسندگان
Michiharu Matsumoto, Hirokazu Kano, Masaaki Suzuki, Taku Katagiri, Yumi Umeda, Shoji Fukushima,