کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5856685 | 1131980 | 2015 | 5 صفحه PDF | دانلود رایگان |
- Nitromezuril (NZL) is a novel compound that exhibits anticoccidial activity.
- The mutagenicity and genotoxicity of NZL were assessed by a battery of tests for the first time.
- NZL showed negative for sperm, micronuclei and chromosomal aberration in mice.
- NZL tested negative for strains TA97 and TA1535, but positive for TA98 and TA100.
Nitromezuril (NZL) is a novel triazine compound that exhibits remarkable anticoccidial activity. However, mutagenicity and genotoxicity of NZL have not been evaluated to date. This study evaluated the potential risks of NZL by testing for bacterial reverse mutation (Ames), mouse sperm abnormality (SA), bone marrow micronucleus (MN) and chromosomal aberration (CA). Mice were orally administered with NZL at 385, 192 and 96Â mg/kg, corresponding to 0.5Ã, 0.25Ã and 0.125Ã the LD50 of NZL, respectively. No significant increases in SA and CA were found in mice treated with NZL for 5Â d and 3Â d, respectively (PÂ >Â 0.05). NZL at 96-385Â mg/kg did not have significant influence on micronucleated polychromatic erythrocyte counts (PÂ >Â 0.05). These results suggest that NZL is not genotoxic. However, Ames test results were positive both with and without the S9 system for Salmonella typhimurium TA98 and TA100, suggesting that NZL may be mutagenic. The mutagenic effects of NZL were different in in vitro and in vivo assays. Further studies should be conducted to confirm the safety of using and developing NZL as a novel anticoccidial drug.
Journal: Regulatory Toxicology and Pharmacology - Volume 71, Issue 3, April 2015, Pages 585-589