کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5856708 1131981 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanoparticles skin absorption: New aspects for a safety profile evaluation
ترجمه فارسی عنوان
جذب نانو ذرات پوست: جنبه های جدید برای ارزیابی مشخصات ایمنی
کلمات کلیدی
جذب نانو ذرات پوست، مرور، اندازه نانو ذرات، شکل، خصوصیات سطحی، تعامل نانوذرات در رسانه فیزیولوژیکی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Nanoparticles (NPs) skin absorption is a wide issue, which needs to be better understood. The attempt of this review is to summarize the scientific evidence concerning open questions, i.e.: the role of NPs intrinsic characteristics (size, shape, charge, surface properties), the penetration of NPs through the intact or impaired skin barrier, the penetration pathways which should be considered and the role of NPs interaction in physiological media. The outcomes suggest that one main difference should be made between metal and non-metal NPs. Both kinds have a secondary NPs size which is given after interaction in physiological media, and allows a size-dependent skin penetration: NPs ⩽ 4 nm can penetrate and permeate intact skin, NPs size between 4 and 20 nm can potentially permeate intact and damaged skin, NPs size between 21 and 45 nm can penetrate and permeate only damaged skin, NPs size > 45 nm cannot penetrate nor permeate the skin. Other aspects play an important role, mostly for metal NPs, i.e., dissolution in physiological media, which can cause local and systemic effects, the sensitizing or toxic potential and the tendency to create aggregates. This paper suggests a decision tree to evaluate the potential risk for consumers and workers exposed to NPs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 72, Issue 2, July 2015, Pages 310-322
نویسندگان
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