Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes

- Cholinesterase was inhibited in humanized mice with liver after oral acephate.
- Plasma acephate and chlorpyrifos in humanized mice supported human concentrations.
- Chimeric mice with a PBPK can evaluate potential of organophosphorus pesticides.