Evaluation of the performance of the reduced local lymph node assay for skin sensitization testing

► Performance of the reduced LLNA was assessed using REACH registrations. ► The reduced LLNA misclassified 3.3% of the sensitizers identified in the LLNA. ► The reduced LLNA is less accurate than the LLNA. ► The reduced LLNA does not provide potency information. ► We do not recommend the use of the reduced LLNA as a standalone method for skin sensitization testing.