کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5856993 | 1131988 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Health assessment of gasoline and fuel oxygenate vapors: Developmental toxicity in rats
ترجمه فارسی عنوان
ارزیابی سلامت بخارات بنزین و اکسیژن سوخت: سمیت رشد در موش صحرایی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Gasoline-vapor condensate (BGVC) or condensed vapors from gasoline blended with methyl t-butyl ether (G/MTBE), ethyl t-butyl ether (G/ETBE), t-amyl methyl ether (G/TAME) diisopropyl ether (G/DIPE), ethanol (G/EtOH), or t-butyl alcohol (G/TBA) were evaluated for developmental toxicity in Sprague-Dawley rats exposed via inhalation on gestation days (GD) 5-20 for 6Â h/day at levels of 0 (control filtered air), 2000, 10,000, and 20,000Â mg/m3. These exposure durations and levels substantially exceed typical consumer exposure during refueling (<1-7Â mg/m3, 5Â min). Dose responsive maternal effects were reduced maternal body weight and/or weight change, and/or reduced food consumption. No significant malformations were seen in any study. Developmental effects occurred at 20,000Â mg/m3 of G/TAME (reduced fetal body weight, increased incidence of stunted fetuses), G/TBA (reduced fetal body weight, increased skeletal variants) and G/DIPE (reduced fetal weight) resulting in developmental NOAEL of 10,000Â mg/m3 for these materials. Developmental NOAELs for other materials were 20,000Â mg/m3 as no developmental toxicity was induced in those studies. Developmental NOAELs were equal to or greater than the concurrent maternal NOAELs which ranged from 2000 to 20,000Â mg/m3. There were no clear cut differences in developmental toxicity between vapors of gasoline and gasoline blended with the ether or alcohol oxygenates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 70, Issue 2, Supplement, 1 November 2014, Pages S69-S79
Journal: Regulatory Toxicology and Pharmacology - Volume 70, Issue 2, Supplement, 1 November 2014, Pages S69-S79
نویسندگان
Linda G. Roberts, Thomas M. Gray, Gary W. Trimmer, Robert M. Parker, F. Jay Murray, Ceinwen A. Schreiner, Charles R. Clark,