کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5857062 1131991 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reproductive and possible hormonal effects of carbendazim
ترجمه فارسی عنوان
اثرات باروری و هورمونی احتمالی کربندازیم
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
This study aimed to better elucidate reproductive and possible hormonal effects of the fungicide carbendazim (CBZ) through a review of published toxicological studies as well as an evaluation of this fungicide in the Hershberger and uterotrophic assays, which are designed to detect in vivo effects of the sex hormones. The literature review indicates that CBZ induces reproductive and developmental toxicity through alteration of many key events which are important to spermatogenesis. The lower dose of CBZ (100 mg/kg) evaluated in the Hershberger test increased prostate weight compared to control group but did not alter the weight of other testosterone-dependent tissues. In the uterotrophic assay, CBZ did not induce an estrogenic or an antiestrogenic effect. In the literature, it has been reported that CBZ may: (1) alter the levels of various hormones (testosterone, LH, FSH, GnRH); (2) negatively influence testicular steroidogenesis; (3) have androgenic effects acting directly in the androgenic receptors and/or increasing the expression of androgen receptors. Despite the contradictory results reported by the different studies that investigated a possible endocrine mode of action of CBZ, it seems that this fungicide may influence the hypothalamus-pituitary-gonad axis in addition to being a testicular toxicant.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 69, Issue 3, August 2014, Pages 476-486
نویسندگان
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