Low-dose effects and nonmonotonic dose-responses of endocrine disrupting chemicals: Has the case been made?

► Vandenberg et al. (2012) claim low-dose effects and nonmonotonicity of EDCs. ► They do not provide sufficient evidence to support their conclusions. ► They overlook evidence contrary to their conclusions. ► They do not evaluate whether exposures are truly low-dose and relevant to humans. ► Many of their examples are not widely endorsed by the scientific community.