کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5857142 1131994 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Malignant pleural mesothelioma in US automotive mechanics: Reported vs expected number of cases from 1975 to 2007
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Malignant pleural mesothelioma in US automotive mechanics: Reported vs expected number of cases from 1975 to 2007
چکیده انگلیسی

Until the 1980s, chrysotile asbestos was a component of automotive brakes manufactured in the US. The current OSHA Bulletin (2006) for brake repair cites a single study (Lemen, 2004) which concluded that the number of mesothelioma cases reported in the literature in “end-product users of friction materials” indicated an asbestos-related risk for auto mechanics. However, Lemen (2004) did not compare the reported number of cases to an “expected” value, even though pleural mesothelioma occurs in the general population in the absence of asbestos exposure. We compare the number of malignant pleural mesothelioma (MPM) cases reported in the US literature among auto mechanics between 1975-2007 to an expected value derived from estimated numbers of current and former auto mechanics. A total of 106 cases categorized as mesothelioma or malignant neoplasm of the pleura were found in the literature. Using background incidence rates for MPM of two and three cases per million individuals per year, we estimated that a range of 278-515 cases of non-asbestos-related MPM, respectively, would have occurred in current or former auto mechanics from 1975-2007. Our findings are consistent with the numerous epidemiology studies that have found no increased risk of MPM in auto mechanics.

► We summed the number of mesotheliomas reported in the literature in auto mechanics. ► We derived an “expected” value based on background incidence and labor statistics. ► A total of 106 cases were found in US auto mechanics in the literature (1975-2007). ► Between 278 and 516 cases would be expected due to background rates alone. ► This is consistent with the studies that report no increased risk in auto mechanics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 64, Issue 1, October 2012, Pages 104-116
نویسندگان
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