Using the fish plasma model for comparative hazard identification for pharmaceuticals in the environment by extrapolation from human therapeutic data

► We studied a model using human drug data to extrapolate long-term fish toxicity. ► We found structurally and functionally conserved drug targets in fish. ► Since many drugs do dissociate, KOW-based accumulation model may yield poor results. ► For worst case scenarios, hazards are indicated for one third of the selected drugs. ► The model is useful to indicate drugs for which long-term evidence seem necessary.