کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5857396 | 1132003 | 2012 | 13 صفحه PDF | دانلود رایگان |

(R)-3-Hydroxybutyl (R)-3-hydroxybutyrate (ketone monoester) has been developed as an oral source of ketones, which may be utilized for energy. In a 28-day toxicity study, Crl:WI (Wistar) rats received diets containing, as 30% of the calories, ketone monoester (12 and 15Â g/kg body weight/day for male and female rats, respectively). Control groups received either carbohydrate- or fat-based diets. Rats in the test group consumed less feed and gained less weight than control animals; similar findings have been documented in studies of ketogenic diets. Between-group differences were noted in selected hematology, coagulation, and serum chemistry parameters; however, values were within normal physiological ranges and/or were not accompanied by other changes indicative of toxicity. Upon gross and microscopic evaluation, there were no findings associated with the ketone monoester. In a developmental toxicity study, pregnant Crl:WI (Han) rats were administered 2Â g/kg body weight/day ketone monoester or water (control) via gavage on days 6 through 20 of gestation. No Caesarean-sectioning or litter parameters were affected by the test article. The overall incidence of fetal alterations was higher in the test group; however, there were no specific alterations attributable to the test substance. The results of these studies support the safety of ketone monoester.
⺠(R)-3-Hydroxybutyl (R)-3-hydroxybutyrate (ketone ester) is an oral source of ketones. ⺠Rats consumed diets containing ketone ester for 28 days. ⺠Consumption of ketone ester did not cause adverse effects in the 28-day study. ⺠Rat development was not adversely affected by in utero exposure to ketone ester. ⺠The results support the safety of ketone ester for use as a dietary source of ketones.
Journal: Regulatory Toxicology and Pharmacology - Volume 63, Issue 2, July 2012, Pages 196-208