Assessment of diurnal systemic dose of agrochemicals in regulatory toxicity testing - An integrated approach without additional animal use

► Detailed procedure for implementing TK in short- and long-term toxicity studies. ► Define kinetically-derived maximum doses (KMD). ► Use of KMD and MTD to select high doses for the subsequent toxicity studies. ► Defines the most appropriate dosing (diet versus gavage) for rabbit dev tox studies. ► Helps understand differences across doses, species, strains, sexes and life stages.