Human safety risk assessment of lymph node angiomas observed in 2-year carcinogenicity studies in rats

► Lymph node angiomas range from rare to common in 2-year carcinogenicity studies. ► Lymph node angiomas are most common in male rats in 2-year carcinogenicity studies. ► Drug-induced mesenteric lymph node angiomas in rats can be up to 40% in male rats. ► Lymph node angiomas in rats are not precursors of lymph node angiosarcomas. ► Lymph node angiomas in rats are not relevant to human risk assessment.