کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5857827 | 1132034 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Subacute toxicity assessment of carotenoids extracted from citrus peel (Nanfengmiju, Citrus reticulata Blanco) in rats Subacute toxicity assessment of carotenoids extracted from citrus peel (Nanfengmiju, Citrus reticulata Blanco) in rats](/preview/png/5857827.png)
The mixture of carotenoids extracted from citrus peel (Nanfengmiju, Citrus reticulata Blanco) was tested for subacute oral toxicity. In this study, dose levels of 0, 200, 500 and 2000Â mg/kg body weight/day were administered by gavage to 10 Wistar rats/sex/group for 28Â days. No statistically significant, dose-related effect on food consumption, food efficiency, body weight gain, clinical signs or ophthalmoscopic parameters was observed in any treatment group. Urinalysis, hematological, blood coagulation and serum biochemical examination as well as necropsy or histopathology showed that no observed adverse effect was found. These findings suggested that the No-Observed-Adverse-Effect Level for the mixture of carotenoids extracted from citrus peel was at least 2000Â mg/kg body weight/day.
⺠In this study, carotenoids were extracted from citrus peel. ⺠Lutein was the major carotenoid in citrus peel extract. ⺠Carotenoids extracted from citrus peel were tested for subacute oral toxicity. ⺠No dose-related toxic effect was found.
Journal: Regulatory Toxicology and Pharmacology - Volume 62, Issue 1, February 2012, Pages 16-22