کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5857893 | 1132056 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Subchronic toxicity of Citrus aurantium L. (Rutaceae) extract and p-synephrine in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Subchronic toxicity of Citrus aurantium L. (Rutaceae) extract and p-synephrine in mice Subchronic toxicity of Citrus aurantium L. (Rutaceae) extract and p-synephrine in mice](/preview/png/5857893.png)
چکیده انگلیسی
Extracts of Citrus aurantium L. (Rutaceae) unripe fruits have gained popularity for the treatment of obesity. Due to the wide use of C. aurantium/p-synephrine-containing products, this research was undertaken to evaluate its subchronic toxicity in mice and their actions in oxidative stress biomarkers. Groups of 9-10 mice received for 28 consecutive days a commercial C. aurantium dried extract (containing 7.5% p-synephrine) 400, 2000 or 4000Â mg/kg and p-synephrine 30 or 300Â mg/kg by oral gavage. There was a reduction in body weight gain of animals treated with both doses of p-synephrine. Organs relative weight, biochemical and hematological parameters were not altered in all treated mice. There was an increase in reduced glutathione (GSH) concentration in groups treated with C. aurantium 4000Â mg/kg and p-synephrine 30 and 300Â mg/kg. In glutathione peroxidase (GPx), there were an inhibition of the activity in C. aurantium 400 and 2000Â mg/kg and p-synephrine 30 and 300Â mg/kg treated animals, respectively, and was no alteration in malondialdehyde (MDA) levels. Thus, the results indicate a low subchronic toxicity of the tested materials in mice and a possible alteration in the oxidative metabolism. However, further tests are required to better elucidate the effects of these compounds in the antioxidant system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 54, Issue 2, July 2009, Pages 114-117
Journal: Regulatory Toxicology and Pharmacology - Volume 54, Issue 2, July 2009, Pages 114-117
نویسندگان
Marcelo Dutra Arbo, Gabriela Cristina Schmitt, Mariana Fagundes Limberger, Mariele Feiffer Charão, Ãngela Maria Moro, Gianine Lima Ribeiro, Eliane Dallegrave, Solange Cristina Garcia, Mirna Bainy Leal, Renata Pereira Limberger,