کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5857919 | 1562154 | 2016 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential effects of high and low strength magnetic fields on mouse embryonic development and vasculogenesis of embryonic stem cells
ترجمه فارسی عنوان
اثرات افتراقی میدان مغناطیسی بالا و پایین بر رشد جنسی موش و عروق کرونر سلول های بنیادی جنین
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Man-made magnetic fields (MFs) may exert adverse effects on mammalian embryonic development. Herein, we analysed the effect of 10Â mT 50Â Hz sinusoidal (AC) or static (DC) MFs versus 1Â mT MFs on embryonic development of mice. Exposure for 20Â days during gestation to 10Â mT MFs increased resorptions and dead fetuses, decreased crown-rump length and fresh weight, reduced blood vessel differentiation and caused histological changes, accompanied with diminished vascular endothelial growth factor (VEGF) protein expression in several organs. In embryonic stem (ES) cell-derived embryoid bodies exposure towards 10Â mT MFs increased reactive oxygen species (ROS), decreased vascular marker as well as VEGF expression and enhanced apoptosis. In conclusion, our combined data from in vivo and in vitro experiments identified VEGF as an important mediator during embryonic development that can be influenced by high strength MFs, which in consequence leads to severe abnormalities in fetus organs and blood vessel formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 65, October 2016, Pages 46-58
Journal: Reproductive Toxicology - Volume 65, October 2016, Pages 46-58
نویسندگان
Mohamed M. Bekhite, Andreas Finkensieper, Fouad A. Abou-Zaid, Ibrahim K. El-Shourbagy, Nabil K. EL-Fiky, Khaled M. Omar, Heinrich Sauer, Maria Wartenberg,