کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5857989 1562158 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exposure to aflatoxin B1 in late gestation alters protein kinase C and apoptotic protein expression in murine placenta
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Exposure to aflatoxin B1 in late gestation alters protein kinase C and apoptotic protein expression in murine placenta
چکیده انگلیسی
Mycotoxins are chemicals with diverse toxicities that are produced by fungi. Aflatoxin B1 is commonly found in plant food, and is generally regarded as one of the most toxic mycotoxins. In the present study, pregnant ICR mice were given p.o. daily doses of aflatoxin B1 at 0, 0.05, 0.5, 5 mg/kg for 4 days (from E13.5 to E16.5). Compared to the control group, time of delivery was shortened and low birth weight was induced in mice treated with 0.5 and 5 mg aflatoxin B1/kg, respectively. Placental tissue isolated from pregnant mice at E17.5 showed that the mRNA expression of crh was increased in aflatoxin-treated groups. This upregulation might signify premature delivery. Further analysis indicated that Pkc proteins were activated and Bcl-2 was reduced in the placental tissue of the aflatoxin-treated groups. Reduction of the anti-apoptotic proteins, on the other hand, might affect the morphorgenesis and maintenance of the placenta.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 61, June 2016, Pages 68-74
نویسندگان
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