کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5858055 1562161 2015 29 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Juvenile exposure to vinclozolin shifts sex ratios and impairs reproductive capacity of zebrafish
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Juvenile exposure to vinclozolin shifts sex ratios and impairs reproductive capacity of zebrafish
چکیده انگلیسی
Exposure to endocrine disruptors during critical periods of development can impact the sustainability of wild fish populations. Anti-androgenic compounds have received less attention, but are capable of modulating gonad differentiation and maturation, and impairing reproduction in fish. The fungicide vinclozolin (VZ) has been shown to impair reproduction in adult fish, but less is known about its effects following exposure earlier in development. Here we show that waterborne exposure to 400 μg VZ/L during critical periods of sex differentiation (21-35 days post fertilization) permanently shifts sex ratios towards females, and alters the maturation of the gonad. Both fecundity and fertility were reduced, even when oogenesis and spermatogenesis recover and sperm motility is not altered. These results demonstrate the need to better understand the impacts of early exposure to anti-androgenic compounds on fish.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 58, December 2015, Pages 111-118
نویسندگان
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