کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5858589 1562171 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microglia toxicity in preterm brain injury
ترجمه فارسی عنوان
سمیت میکروگلاییا در آسیب زودرس مغز
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Microglia responses in the preterm human brain in association with injury.
- Microglia responses in animal models of preterm brain injury.
- Mechanisms of microglia toxicity from in vitro primary microglia cell culture experiments.

Microglia are the resident phagocytic cells of the central nervous system. During brain development they are also imperative for apoptosis of excessive neurons, synaptic pruning, phagocytosis of debris and maintaining brain homeostasis. Brain damage results in a fast and dynamic microglia reaction, which can influence the extent and distribution of subsequent neuronal dysfunction. As a consequence, microglia responses can promote tissue protection and repair following brain injury, or become detrimental for the tissue integrity and functionality. In this review, we will describe microglia responses in the human developing brain in association with injury, with particular focus on the preterm infant. We also explore microglia responses and mechanisms of microglia toxicity in animal models of preterm white matter injury and in vitro primary microglia cell culture experiments.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 48, September 2014, Pages 106-112
نویسندگان
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