کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5858781 1562178 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alobar holoprosencephaly with cyclopia - Autopsy-based observations from one medical center
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Alobar holoprosencephaly with cyclopia - Autopsy-based observations from one medical center
چکیده انگلیسی


- Alobar holoprosencephaly with cyclopia was analyzed on the basis of autopsy reports performed for hospitals admitting patients from the Lublin Region in Eastern Poland in the period of 20 years (1981-2000).
- The malformation was found in seven newborns - five girls, one boy and one child with sex not established due to agenesia of the genital organs, all autopsied in the years 1990-1999.
- According to clinical data, none of the woman was exposed to any prescribed or over-the-counter (OTC) drugs during pregnancy, but one was exposed to paints at early pregnancy.
- The proboscis was present in four of seven cases. Six of seven children displayed additional congenital malformations.
- An intrapancreatic accessory spleen found in two children arises suspicion of trisomy 13.

Holoprosencephaly, a major congenital malformation of the brain, consists in a complete or partial failure of the prosencephalon to divide into separate hemispheres. Alobar holoprosencephaly with cyclopia was analyzed on the basis of autopsy reports performed for hospitals admitting patients from the Lublin Region in Eastern Poland in the period of 20 years (1981-2000). The malformation was found in seven newborns - five girls, one boy and one child with sex not established due to agenesia of the genital organs, all autopsied in the years 1990-1999. According to clinical data, none of the mothers (age 24-39 years) was exposed to any prescribed or over-the-counter (OTC) drugs during pregnancy, but one was exposed to paints in early pregnancy. The proboscis was present in four of seven cases. Six of seven children displayed additional congenital malformations. In two cases intrapancreatic accessory spleen suggesting trisomy 13 was found. Alobar holoprosencephaly with cyclopia is a rare lethal congenital anomaly frequently accompanied by other malformations and characterized by large variations in incidence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 41, November 2013, Pages 80-85
نویسندگان
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