کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5860191 1133169 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies
ترجمه فارسی عنوان
عصبی سلنیوم در انسان: مطالعات آزمایشی و اپیدمیولوژیک
کلمات کلیدی
سلنیوم، سندرم های عصبی-عصبی، بیماری های دستگاه عصبی، اسکلروز جانبی جانبی آمیوتروفیک، مطالعات اپیدمیولوژیک، ارزیابی ریسک،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Acute overexposure to the metalloid selenium (Se) is neurotoxic in the human.
- Neurotoxicity of chronic Se overexposure needs to be better characterized.
- Chronic Se overexposure might induce lethargy and amyotrophic lateral sclerosis.
- The different Se chemical species strongly vary in their neurotoxic effects.
- Peripheral biomarkers of Se exposure may not reflect Se central nervous system levels.

Selenium is a metalloid of considerable interest in the human from both a toxicological and a nutritional perspective, with a very narrow safe range of intake. Acute selenium intoxication is followed by adverse effects on the nervous system with special clinical relevance, while the neurotoxicity of long-term overexposure is less characterized and recognized. We aimed to address this issue from a public health perspective, focusing on both laboratory studies and the few epidemiologic human studies available, with emphasis on their methodological strengths and limitations. The frequently overlooked differences in toxicity and biological activity of selenium compounds are also outlined. In addition to lethargy, dizziness, motor weakness and paresthesias, an excess risk of amyotrophic lateral sclerosis is the effect on the nervous system which has been more consistently associated with chronic low-level selenium overexposure, particularly to its inorganic compounds. Additional research efforts are needed to better elucidate the neurotoxic effects exerted by selenium overexposure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 230, Issue 2, 15 October 2014, Pages 295-303
نویسندگان
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