HIF-1α and HIF-2α are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-1α-mediated fatty acid β-oxidation

- Hypoxia or CoCl2 treatment induced hepatic intracellular fat accumulation.
- Hypoxia or CoCl2 treatment impaired fatty acid β-oxidation mediated by PGC-α.
- Both HIF-1α and HIF-2α are critically involved in hypoxia-induced lipid accumulation in hepatocytes.