کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5860378 1133182 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tributyltin contributes in reducing the vascular reactivity to phenylephrine in isolated aortic rings from female rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Tributyltin contributes in reducing the vascular reactivity to phenylephrine in isolated aortic rings from female rats
چکیده انگلیسی
Organotin compounds such as tributyltin (TBT) are used as antifouling paints by shipping companies. TBT inhibits the aromatase responsible for the transformation of testosterone into estrogen. Our hypothesis is that TBT modulates the vascular reactivity of female rats. Female Wistar rats were treated daily (Control; CONT) or TBT (100 ng/kg) for 15 days. Rings from thoracic aortas were incubated with phenylephrine (PHE, 10−10−10−4 M) in the presence and absence of endothelium, and in the presence of NG-Nitro-l-Arginine Methyl Ester (l-NAME), tetraethylammonium (TEA) and apocynin. TBT decreased plasma levels of estrogen and the vascular response to PHE. In the TBT group, the vascular reactivity was increased in the absence of endothelium, l-NAME and TEA. The decrease in PHE reactivity during incubation with apocynin was more evident in the TBT group. The sensitivity to acetylcholine (ACh) and sodium nitroprusside (SNP) was reduced in the TBT group. TBT increased collagen, reduced α1-smooth muscle actin. Female rats treated with TBT for 15 days showed morphology alteration of the aorta and decreased their vascular reactivity, probably due to mechanisms dependent on nitric oxide (NO) bioavailability, K+ channels and an increase in oxidative stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 225, Issue 3, 21 March 2014, Pages 378-385
نویسندگان
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