کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5860517 | 1133188 | 2013 | 7 صفحه PDF | دانلود رایگان |
- A chemically induced animal model of the human MRKH syndrome.
- A phthalate syndrome in female rats: uterine and vaginal agenesis.
- A phthalate mixture disrupts male and female rat sexual differentiation.
- Differences in critical periods for disrupted sex differentiation and mortality.
Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by uterine and vaginal canal aplasia in normal karyotype human females and is a syndrome with poorly defined etiology. Reproductive toxicity of phthalate esters (PEs) occurs in rat offspring exposed in utero, a phenomenon that is better studied in male offspring than females. The current study reports female reproductive tract malformations in the Sprague-Dawley rat similar to those characteristic of MRKH syndrome, following in utero exposure to a mixture of 5 PEs. We determined that females are â¼2-fold less sensitive to the effects of the 5-PE mixture than males for reproductive tract malformations. We were not fully successful in defining the critical exposure period for females; however, incidence of malformations was 88% following dosing from GD8 to 19 versus 22% and 0% for GD8-13 and GD14-19, respectively. Overall, this study provides valuable information regarding female vulnerability to in utero phthalate exposure and further characterizes a potential model for the human MRKH syndrome.
Journal: Toxicology Letters - Volume 223, Issue 3, 16 December 2013, Pages 315-321