Involvement of dopaminergic and serotonergic systems in the neurobehavioral toxicity of lambda-cyhalothrin in developing rats

► Vulnerability of developing rats to lambda-cyhalothrin at dose 1/60 and 1/20 of LD50 demonstrated. ► Post-lactational exposure to lambda-cyhalothrin decreased rat striatal DA-D2 receptors. ► Decreased DA-D2 receptors associated with impaired motor activity and coordination on PD50 and PD65. ► Involvement of 5-HT2A receptors in the neurotoxicity of lambda-cyhalothrin shown. ► Neurobehavioral changes may be intense if exposure to lambda-cyhalothrin continues.