Perturbation of Myelin basic protein (Mbp) splice variant expression in developing rat cerebellum following perinatal exposure to methylmercury

► Myelin basic protein (Mbp) gene produces alternate transcripts by splicing. ► We identified a new Mbp splice variant in rat expressed in developing brain. ► We developed a PCR-based approach to properly measure all Mbp splice variants. ► As expected, perinatal exposure to methylmercury decreased Mbp gene expression. ► Methylmercury did not impact the relative expression of Mbp splice variants.