Dihydrolipoamide dehydrogenase and cAMP are associated with cadmium-mediated Leydig cell damage

► Cd inhibited steroidogenesis in R2C Leydig cells. ► Cd reduced mitochondria membrane potential. ► Cd downregulated the expression of dihydrolipoamide dehydrogenase in R2C cells. ► Cd lowered cAMP levels in R2C cells.