کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5860776 | 1133239 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Permethrin modulates cholinergic mini-synaptic currents by partially blocking the calcium channel
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Pyrethroid insecticide modulation of the voltage-gated sodium channel (VGSC) is proposed to underlie their effects on neuronal excitability by inhibiting channel inactivation and increasing channel open time. However, some in vitro evidences indicate that target sites other than VGSCs could contribute to pyrethroid disruption of neuronal activity. Cholinergic excitability in Drosophila, as in other insects and mammals, is important for activity in the central nervous system. The effects of permethrin, a putative calcium antagonist, on calcium current and cholinergic mini-synaptic transmission were investigated in the Drosophila brain. At concentration of 2.5 μM, permethrin significantly decreased the calcium current and cholinergic mini-synaptic current. However, the permethrin could not antagonize the calcium current completely. Removal of calcium from the external solution produced a significant decrease of cholinergic mini-synaptic transmission. The results are consistent with the hypothesis that permethrin may modulate cholinergic mini-synaptic currents by partially blocking the calcium channel.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 201, Issue 3, 25 March 2011, Pages 258-263
Journal: Toxicology Letters - Volume 201, Issue 3, 25 March 2011, Pages 258-263
نویسندگان
Ying Yan, Ying Yang, Jing You, Guangxin Yang, Ye Xu, Naya Huang, Xutian Wang, Dongzhi Ran, Xi Yuan, Ying Jin, Yuting Fan, Jiayao Lei, Weicong Li, Huaiyu Gu,