Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanism

- The estrogenic activities of several EDs were measured by an ERE-luciferase bioassay.
- Xenoestrogens decreased ARNT2 expression in MCF-7 cells in a dose-dependent manner.
- ESR1 antagonist MPP inhibited the xenoestrogen-mediated decrease in ARNT2 expression.
- No significant effects were found in ER-negative LNCaP cells.