Immunoregulatory potential of marine algal toxins yessotoxin and okadaic acid in mouse T lymphocyte cell line EL-4

► YTX and OA affect TCR recycling kinetics in T lymphocyte EL-4 cells. ► YTX induces TCR down-regulation via PKC-dependent and independent pathways. ► OA-induced TCR down-regulation is mediated by PP2A inhibition. ► This study will help to clarify the molecular mechanisms determining kout.