کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5860964 | 1133273 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Potential mechanisms involved in the absorptive transport of cadmium in isolated perfused rabbit renal proximal tubules
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Potential mechanisms involved in the absorptive transport of cadmium in isolated perfused rabbit renal proximal tubules Potential mechanisms involved in the absorptive transport of cadmium in isolated perfused rabbit renal proximal tubules](/preview/png/5860964.png)
چکیده انگلیسی
Lumen-to-cell transport, cellular accumulation, and toxicity of cadmium as ionic cadmium (Cd2+) or as the l-cysteine (Cys) or d,l-homocysteine (Hcy) S-conjugate of cadmium (Cys-S-Cd-S-Cys, Hcy-S-Cd-S-Hcy) were studied in isolated, perfused rabbit proximal tubular segments. When Cd2+ (0.73 μM) or Cys-S-Cd-S-Cys (0.73 μM) was perfused through the lumen of S2 segments of the proximal tubule, no visual evidence of cellular pathological changes was detected during 30 min of study. Cd2+-transport was temperature-dependent and was inhibited by Fe2+, Zn2+, and elevated concentrations of Ca2+. Luminal uptake of Cys-S-Cd-S-Cys was also temperature-dependent and was inhibited by the amino acids l-cystine and l-arginine, while stimulated by l-methionine. Neither l-aspartate, l-glutamate, the synthetic dipeptide, Gly-Sar nor Zn2+ had any effect on the rate of Cys-S-Cd-S-Cys transport. Conclusions: When delivered to the luminal compartment, Cd2+ appears to be capable of utilizing certain transporter(s) of Zn2+ and some transport systems sensitive to Ca2+ and Fe2+. In addition, Cys-S-Cd-S-Cys and Hcy-S-Cd-S-Hcy appear to be transportable substrates of one or more amino acid transporters participating in luminal absorption of the amino acid l-cystine (such as system b0,+). These findings indicate that multiple mechanisms could be involved in the luminal absorption of cadmium (Cd) in proximal tubular segments depending on its form. These findings provide a focus for future studies of Cd absorption in the proximal tubule.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 193, Issue 1, 1 March 2010, Pages 61-68
Journal: Toxicology Letters - Volume 193, Issue 1, 1 March 2010, Pages 61-68
نویسندگان
Yanhua Wang, Rudolfs K. Zalups, Delon W. Barfuss,