کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5861951 1133770 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Screening for potential hazard effects from four nitramines on human eye and skin
ترجمه فارسی عنوان
غربالگری برای اثرات بالقوه خطر از چهار نیتروامین بر روی چشم و پوست انسان
کلمات کلیدی
نیترامین، تست انسانی در انسان، تست تحریک پوست، آزمون خوردگی پوست، آزمون حساسیت پوست، آزمون تحریک چشم،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی

Amines have potential to be used in CO2 capture and storage (CCS) technology, but as they can be released into the environment and be degraded into more toxic compounds, such as nitrosamines and nitramines, there have been concerns about their negative impact on human health. We investigated the potential toxic effects from acute exposure to dimethylnitramine (DMA-NO2), methylnitramine (MA-NO2), ethanolnitramine (MEA-NO2) and 2-methyl-2-(nitroamino)-1-propanol (AMP-NO2). The eye irritation, and skin sensitization, irritation and corrosion potential of these substances have been evaluated in vitro using the Bovine Corneal Opacity and Permeability (BCOP) assay, VITOSENS® assay, Reconstructed Human Epidermis (RHE) skin irritation test and Corrositex Skin corrosion test, respectively. Exposure to DMA-NO2 induced a mild eye irritation response, while MA-NO2, MEA-NO2 and AMP-NO2 were shown to be very severe eye irritants. MA-NO2 and MEA-NO2 were tested for skin sensitization and found to be non-sensitizers to the skin. In addition, none of the four test substances was irritant or corrosive to the skin.

► Four nitramines were investigated for toxic effects on in vitro skin and eye models. ► 2-Methyl-2-(nitroamino)-1-propanol, methyl- and ethanolnitramine were very severe irritants to eye. ► Dimethylnitramine was observed to be a mild eye irritant. ► Methyl- and ethanolnitramine were tested for skin sensitisation with no effect. ► None of the four tested nitramines were irritant or corrosive to skin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 27, Issue 4, June 2013, Pages 1205-1210
نویسندگان
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