کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5861954 1133770 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of CdCl2 on Regulatory Volume Decrease (RVD) in Mytilus galloprovincialis digestive cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Effect of CdCl2 on Regulatory Volume Decrease (RVD) in Mytilus galloprovincialis digestive cells
چکیده انگلیسی

This study investigated the role of cadmium, a widespread heavy metal in the aquatic environment, on cell volume regulation of digestive cells isolated from the digestive gland of Mytilus galloprovincialis. These cells when exposed to a rapid change (from 1100 to 800 mOsm/kg) of the bathing solution osmolality swelled but thereafter underwent a Regulatory Volume Decrease (RVD), tending to recover the original size. This homeostatic response is altered by cadmium, as suggested by experiments performed both on isolated cells pre-incubated with cadmium (10−5 M) and on cells isolated from animals exposed to sub-lethal concentrations of the metal (40 μg/l for 21 days). It is suggested that cytoskeleton and Na+/K+ATPase are the possible targets of cadmium which impairment is responsible of the altered homeostatic response.

► Cadmium impairs Regulatory Volume Decrease in digestive cells of mussel digestive gland. ► Studies on cell volume regulation could be useful to assess cellular effects of metals. ► Cytoskeleton and Na+/K+ATPase possible cellular targets of cadmium.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 27, Issue 4, June 2013, Pages 1260-1266
نویسندگان
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