کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5861954 | 1133770 | 2013 | 7 صفحه PDF | دانلود رایگان |
This study investigated the role of cadmium, a widespread heavy metal in the aquatic environment, on cell volume regulation of digestive cells isolated from the digestive gland of Mytilus galloprovincialis. These cells when exposed to a rapid change (from 1100 to 800 mOsm/kg) of the bathing solution osmolality swelled but thereafter underwent a Regulatory Volume Decrease (RVD), tending to recover the original size. This homeostatic response is altered by cadmium, as suggested by experiments performed both on isolated cells pre-incubated with cadmium (10â5 M) and on cells isolated from animals exposed to sub-lethal concentrations of the metal (40 μg/l for 21 days). It is suggested that cytoskeleton and Na+/K+ATPase are the possible targets of cadmium which impairment is responsible of the altered homeostatic response.
⺠Cadmium impairs Regulatory Volume Decrease in digestive cells of mussel digestive gland. ⺠Studies on cell volume regulation could be useful to assess cellular effects of metals. ⺠Cytoskeleton and Na+/K+ATPase possible cellular targets of cadmium.
Journal: Toxicology in Vitro - Volume 27, Issue 4, June 2013, Pages 1260-1266