3-Thiomethyl-5,6-(dimethoxyphenyl)-1,2,4-triazine improves neurite outgrowth and modulates MAPK phosphorylation and HSPs expression in H2O2-exposed PC12 cells

► TDMT improved neurite outgrowth in H2O2-exposed PC12 cells. ► TDMT improved neurite complexity in H2O2-exposed PC12 cells. ► TDMT treatment reduced phosphorylated p38, ERK1/2 and JNK levels in PC12 cells. ► TDMT resulted in induction of Hsp-70 and reduction of Hsp-90 in PC12 cells.