Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells

► NFD inhibited the EGF-induced cells invasion and migration. ► NFD suppressed MMP-9 activity. ► NFD reduced AP-1. ► NFD abrogated EGFR and PI3K/Akt activation.