Histamine at low concentrations aggravates rat liver BRL-3A cell injury induced by hypoxia/reoxygenation through histamine H2 receptor in vitro

► Histamine below 10−7 M aggravates BRL-3A cell damages triggered by hypoxia/reoxygenation. ► The deleterious effects of histamine are through histamine H2 receptor. ► Histamine alone does not affect the viability rates of BRL-3A cell under normal condition.