Repair pathways evident in human liver organ slices

► Extended viability of human liver slice model to support mechanistic multiple dosing studies. ► Synthesis and maintenance of ATP, GSH and intracellular K+ levels. ► High RNA quality for gene expression profiling by microarray and qRT-PCR technologies. ► Pathways of regeneration were activated, including demonstrating role of stellate cells. ► The model will have the potential for monitoring both injury and repair pathways.